Convenient, once-daily oral dosing with Oxbryta1*
The recommended dosage of Oxbryta for adults and pediatric patients 12 years and older is 1,500 mg orally once daily
Once daily
If a dose is missed or entire dose is not taken, resume dosing the following day
3 pills
(1,500 mg)
Without the need for titration
With or without food
Patients should swallow Oxbryta tablets whole. Do not cut, crush, or chew the tablets
With or without
hydroxyurea
No laboratory monitoring of Oxbryta required
*Please see Full Prescribing Information and Patient Prescribing Information for complete information on Dosage and Administration.
Recommended dosage for adults and pediatric patients 12 years and older with hepatic impairment
- The recommended dosage of Oxbryta in adults and pediatric patients 12 years and older with severe hepatic impairment (Child-Pugh C) is 1,000 mg orally once daily
- No dosage adjustment of Oxbryta is required for patients with mild or moderate hepatic impairment
Recommended dosage of Oxbryta for adults and pediatric patients 12 years and older when used with concomitant strong or moderate CYP3A4 inducers
- Avoid concomitant use of strong or moderate CYP3A4 inducers with Oxbryta
- If concomitant use of strong CYP3A4 inducers is unavoidable, the recommended dosage of Oxbryta is 2,500 mg orally once daily. If concomitant use of moderate CYP3A4 inducers is unavoidable, the recommended dosage of Oxbryta is 2,000 mg orally once daily
Dosing recommendations for Oxbryta in pediatric patients ages 4 to less than 12 years is based on patient's ability to swallow tablets and patient weight
Once daily
If a dose is missed or entire dose is not taken, resume dosing the following day
With or without food
Do not swallow whole, cut, crush, or chew the tablets for oral suspension. Please see administration instructions below
With or without
hydroxyurea
No laboratory monitoring of Oxbryta required
*Please see Full Prescribing Information and Instructions for Use for complete information on Dosage and Administration.
*Please see Full Prescribing Information and Instructions for Use for complete information on Dosage and Administration.
Important administration instructions
- Immediately before administration, disperse tablets for oral suspension in room temperature clear liquid (such as drinking water or clear soda) in a cup:
Recommended Daily Dose
Number of Tablets
for Oral Suspension
Minimum Recommended
Volume of Clear Drink
300 mg
1
5 mL (1 teaspoon)
600 mg
2
10 mL (2 teaspoons)
900 mg
3
15 mL (3 teaspoons)
1,200 mg
4
20 mL (4 teaspoons)
1,500 mg
5
25 mL (5 teaspoons)
2,100 mg
7
35 mL (7 teaspoons)
2,400 mg
8
40 mL (8 teaspoons)
- After the tablets start to disintegrate, swirl the contents of the cup until the tablets are dispersed, wait 1 to 5 minutes, swirl the contents of the cup again, and then orally administer the contents of the cup. The tablet(s) will not completely dissolve; there will still be small tablet clumps in the mixture.
- Resuspend any residue left in the cup in more clear drink and administer. Repeat until no tablet residue is left in the cup.
Tablets for oral suspension may be substituted for tablets in adults and pediatric patients 12 years and older with difficulty swallowing the tablets. Use the number of tablets for oral suspension needed to achieve the recommended dose.
*Please see Full Prescribing Information and Instructions for Use for complete information on Dosage and Administration.
