Convenient, once-daily oral dosing with Oxbryta1*

The recommended starting dose for Oxbryta is 1,500 mg

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Once daily

If a dose is missed, continue dosing on the day following the missed dose

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3 pills
(1,500 mg)

Without the need for titration

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With or without food

Patients should swallow Oxbryta tablets whole. Do not cut, crush, or chew the tablets

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With or without
hydroxyurea

*For complete information about dosage and administration, please see Full Prescribing Information.
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Dose adjustments1

  • In patients with severe hepatic impairment (Child-Pugh C), the recommended daily dose is 1,000 mg (2 tablets)
    • No dose adjustment needed for patients with mild or moderate hepatic impairment
  • Avoid concomitant use of strong or moderate CYP3A4 inducers, strong CYP3A4 inhibitors, or fluconazole with Oxbryta. If concomitant use is unavoidable, adjust the dose as follows:
    • 1,000 mg once daily with strong CYP3A4 inhibitors or fluconazole
    • 2,500 mg once daily with strong or moderate CYP3A4 inducers

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